The transition from secondary to primary care can be daunting for any healthcare professional due to the extreme changes in the working environment and clinical responsibilities/duties undertaken. Healthcare professionals may fear that their knowledge base is not up-to-date and that they will become ‘deskilled’ within the general practice setting. However, with the correct attitude and determination, a successful and varied career can be forged incorporating advanced skills and enhanced practice within the day-to-day work of a general practice nurse (GPN).