Despite the widespread reported health benefits associated with increased physical activity (PA) and exercise, in reality, a large percentage of adults and children in the UK today are inactive and levels of obesity and life-threatening conditions associated with sedentary and unhealthy lifestyles are increasing (National Institute for Health and Care Excellence [NICE], 2015). Chronic diseases are on the increase, including diabetes, hypertension, bone and joint diseases, cancer and depression, and are affecting both the young and old. Regular PA can guard against these life-changing conditions (Public Health England [PHE], 2014). General practice nurses (GPNs) are ideally placed to advise patients about the benefits of PA. This article provides an overview of recommendations and any safety aspects, current fitness terminology, as well as the importance of exploring patient perspectives in terms of perceived barriers to PA.