This article discusses key concepts that general practice nurses (GPNs) can consider when supporting men with longterm conditions (LTCs) in primary care. It looks at relevant statistics alongside common LTCs GPNs may see in primary care, and offers practice points to help GPNs feel more confident in addressing men’s health in those with LTCs. It also explores barriers that may prevent men from accessing healthcare services. By considering these points in primary care, GPNs can better advocate for male patients and improve outcomes.