Hypothyroidism is a common endocrine condition characterised by an underactive thyroid gland, resulting in a deficiency of thyroid hormones. It presents with variable symptoms, which can range from mild such as fatigue and dry skin, to more severe, such as shortness of breath. As it shares fairly wide ranging symptoms with many other common conditions, such as depression, menopause, etc, it can sometimes be missed. If left untreated, the outcome can be fatal. The condition is often diagnosed and treated in the primary care setting, and this article gives nurses and nonmedical prescribers an overview of the disease with the aim of helping them recognise and treat this condition, so as to improve outcomes and quality of life.