Intertriginous dermatitis is a common inflammatory condition affecting opposing skin surfaces within anatomical folds, arising from the combined effects of moisture, friction and impaired barrier function. It is increasingly recognised as a subtype of moisture-associated skin damage and represents a significant burden across acute, community and long-term care settings, particularly among older adults and individuals with multimorbidity. This article examines the epidemiology, risk factors and pathophysiology of intertrigo, with particular emphasis on populations at heightened risk, including those with obesity, diabetes mellitus, immobility or continence impairment. It outlines a structured approach to history-taking, clinical examination and differential diagnosis, highlighting challenges related to skin tone variation and the identification of secondary infection. Evidence-informed management strategies are discussed, encompassing uncomplicated intertrigo, infection-associated disease and targeted care for high-risk anatomical sites. The article emphasises the central role of general practice nurses in early recognition, accurate clinical assessment, antimicrobial stewardship and preventative leadership. A proactive, person-centred approach to prevention and longterm management is advocated to reduce recurrence, prevent complications, and improve patient outcomes.