Here, Callum Metcalfe-O’Shea, advanced nurse practitioner diabetes specialist and co-chair for the Practice Nurse Diabetes Forum for Norfolk, provides the first in a series of articles with direct insight into the changing practice of diabetes in primary care and how general practice nurses (GPNs) can keep up to date with new evidence. This article looks at new guidance from the National Institute for Health and Care Excellence (NICE) for type 2 diabetes, identifying how the implementation of sodiumglucose co-transporter-2 inhibitors (SGLT-2i) as second-line therapy now takes place and how you can use these guidelines to advance practice. Consideration will be given to SGLT-2i use in practice, while recognising the importance of patient preference and individualised care at all stages.